Highlighted Publications:

Escoubas, C. C.*; Dorman, L. C.*; Nguyen, P. T.; Lagares-Linares, C.; Nakajo, H.; Anderson, S. R.; Barron, J. J.; Wade, S. D.; Cuevas, B.; Vainchtein, I. D.; Silva, N. J.; Guajardo, R.; Xiao, Y.; Lidsky, P. V.; Wang, E. Y.; Rivera, B. M.; Taloma, S. E.; Kim, D. K.; Kaminskaya, E.; Nakao-Inoue, H.; Schwer, B.; Arnold, T. D.; Molofsky, A. B.; Condello, C.; Andino, R.; Nowakowski, T. J.; Molofsky, A. V. Type-I-Interferon-Responsive Microglia Shape Cortical Development and Behavior. Cell 2024 DOI: 10.1016/j.cell.2024.02.020. Full Text . See spotlights in Trends in Immunology and Neuron.

Nguyen, P.T., Dorman, L.C., Pan, S., Vainchtein, I.D., Han, R.T., Nakao-Inoue, H., Taloma, S.E., Barron, J.J., Molofsky, A.B., Kheirbek, M.A., Molofsky, A.V. Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity. Cell 2020 182, 1–16. Text. See features in Cell and Nature Reviews Neuroscience.

Vainchtein ID*, Chin G*, Cho FS, Kelley KW, Miller JG, Chien EC, Liddelow SA, Nguyen PT, Nakao-Inoue H, Dorman LC, Akil O, Joshita S, Barres BA, Paz JT, Molofsky AB, Molofsky AV (2018). Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development. Science 2018 359:1269-1273. Links to: Abstract PDF  Full text . See features in Immunity and Nature Reviews Neuroscience. 

All publications:

Escoubas, C. C.*; Dorman, L. C.*; Nguyen, P. T.; Lagares-Linares, C.; Nakajo, H.; Anderson, S. R.; Barron, J. J.; Wade, S. D.; Cuevas, B.; Vainchtein, I. D.; Silva, N. J.; Guajardo, R.; Xiao, Y.; Lidsky, P. V.; Wang, E. Y.; Rivera, B. M.; Taloma, S. E.; Kim, D. K.; Kaminskaya, E.; Nakao-Inoue, H.; Schwer, B.; Arnold, T. D.; Molofsky, A. B.; Condello, C.; Andino, R.; Nowakowski, T. J.; Molofsky, A. V. Type-I-Interferon-Responsive Microglia Shape Cortical Development and Behavior. Cell 2024 DOI: 10.1016/j.cell.2024.02.020. Full Text . See spotlights in Trends in Immunology and Neuron.

Escoubas, C. C.; Molofsky, A. V. Microglia as Integrators of Brain-Associated Molecular Patterns. Trends Immunol. 2024 DOI: 10.1016/j.it.2024.03.009. (review) Full Text.

Szewczyk, L. M.; Lipiec, M. A.; Liszewska, E.; Meyza, K.; Urban-Ciecko, J.; Kondrakiewicz, L.; Goncerzewicz, A.; Rafalko, K.; Krawczyk, T. G.; Bogaj, K.; Vainchtein, I. D.; Nakao-Inoue, H.; Puscian, A.; Knapska, E.; Sanders, S. J.; Jan Nowakowski, T.; Molofsky, A. V.; Wisniewska, M. B. Astrocytic β-Catenin Signaling via TCF7L2 Regulates Synapse Development and Social Behavior. Mol. Psychiatry 2023 DOI: 10.1038/s41380-023-02281-y. Full Text.

Rosenberg, M. F.; Godoy, M. I.; Wade, S. D.; Paredes, M. F.; Zhang, Y.; Molofsky, A. V. β-Adrenergic Signaling Promotes Morphological Maturation of Astrocytes in Female Mice. J. Neurosci. 2023 DOI: 10.1523/JNEUROSCI.0357-23.2023. Full Text.

Han, Rafael T., Ilia D. Vainchtein, Johannes C. M. Schlachetzki, Frances S. Cho, Leah C. Dorman, Eunji Ahn, Dong Kyu Kim, et al. 2023. “Microglial Pattern Recognition via IL-33 Promotes Synaptic Refinement in Developing Corticothalamic Circuits in Mice.” The Journal of Experimental Medicine 220 (2). https://doi.org/10.1084/jem.20220605. Full Text.

Cho FS, Vainchtein ID, Voskobiynyk Y, Morningstar AR, Aparicio F, Higashikubo B, Ciesielska A, Broekaart DWM, Anink JJ, van Vliet EA, Yu X, Khakh BS, Aronica E, Molofsky AV, Paz JT. Enhancing GAT-3 in thalamic astrocytes promotes resilience to brain injury in rodents. Sci Transl Med. 2022 Jul 6;14(652):eabj4310. doi: 10.1126/scitranslmed.abj4310. Epub 2022 Jul 6. PMID: 35857628.

Kuhn J, Vainchtein ID, Braz JM, Hamel K, Bernstein M, Craik V, Dahlgren MW, Ortiz-Carpena J, Molofsky AB, Molofsky AV, Basbaum A. Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice. Elife. 2021 Oct 15;10:e69056. doi: 10.7554/eLife.69056. Link. See feature in Elife here.

Silva, N.J., Dorman, L.C., Vainchtein, I.D., Horneck, N, Molofsky, A.V. (2021). In situ and transcriptomic identification of microglia in synapse-rich regions of the developing zebrafish brain. Nat Commun 12, 5916. Text.

Han RT, Kim RD, Molofsky AV, Liddelow SA. (2021). Astrocyte-immune cell interactions in physiology and pathology. Immunity 54(2):211-224. (review) Full text.

Nguyen, P.T., Dorman, L.C., Pan, S., Vainchtein, I.D., Han, R.T., Nakao-Inoue, H., Taloma, S.E., Barron, J.J., Molofsky, A.B., Kheirbek, M.A., Molofsky, A.V. (2020). Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity. Cell 182, 1–16. Text. See features in Cell and Nature Reviews Neuroscience.

Vainchtein, I.D., and Molofsky, A. V. (2020). Astrocytes and Microglia: In Sickness and in Health. Trends Neurosci. 1–11. (review) Text.

Bennett FC, Molofsky AV. The immune system and psychiatric disease: a basic science perspective (2019). Clin Exp Immunol. 197:294-307. Text.

Vainchtein ID*, Chin G*, Cho FS, Kelley KW, Miller JG, Chien EC, Liddelow SA, Nguyen PT, Nakao-Inoue H, Dorman LC, Akil O, Joshita S, Barres BA, Paz JT, Molofsky AB, Molofsky AV (2018). Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development. Science 359:1269-1273. Links to: Abstract PDF  Full text . See features in Immunity and Nature Reviews Neuroscience. 

Kelley KW, Nakao-Inoue H, Molofsky AV, Oldham M (2018) Variation among intact tissue samples reveals the core transcriptional features of human CNS cell classes. Nature Neuroscience 21:1171–1184.

Poskanzer KE and Molofsky AV (2018) Dynamism of an Astrocyte In Vivo: Perspectives on Identity and Function. Ann Rev Physiol 80:143-157. (review)

Complete list of published work: http://www.ncbi.nlm.nih.gov/pubmed/?term=molofsky+av