Recent Publications:

Vainchtein ID*, Chin G*, Cho FS, Kelley KW, Miller JG, Chien EC, Liddelow SA, Nguyen PT, Nakao-Inoue H, Dorman LC, Akil O, Joshita S, Barres BA, Paz JT, Molofsky AB, Molofsky AV (2018). Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development. Science 359:1269-1273. Links to: Abstract PDF  Full text . See features in Immunity and Nature Reviews Neuroscience

Kelley KW, Nakao-Inoue H, Molofsky AV, Oldham M (2018) Variation among intact tissue samples reveals the core transcriptional features of human CNS cell classes. Nature Neuroscience 21:1171–1184.

Poskanzer KE and Molofsky AV (2018) Dynamism of an Astrocyte In Vivo: Perspectives on Identity and Function. Ann Rev Physiol 80:143-157.

Molofsky AV and Deneen B (2015) Astrocyte development: a guide for the perplexed. Glia, 63:1320-9.

Prior to 2015:

Molofsky AV, Kelley KW, Tsai HH, Redmond SA, Chang S, Madireddy L, Chan JR, Baranzini SE, Ullian EM, Rowitch DH (2014). Astrocyte-encoded positional cues maintain sensorimotor circuit integrity. Nature 509:189-194

Molofsky AV, Glasgow S, Chaboub L, Tsai HH, Murnen AT, Fancy SPJ, Yuen T, Mahireddy L, Baranzini S, Deneen B, Rowitch DH, Oldham M. (2013). Expression profiling of Aldh1l1-precursors in the developing spinal cord reveals glial lineage-specific genes and direct Sox9-Nfe2l1 interactions. Glia 61, 1518–1532.

Molofsky AV, Krencik R, Ullian E, Tsai HH, Deneen B, Richardson WD, Barres BA, Rowitch DH (2012). Astrocytes and disease: a neurodevelopmental perspective. Genes and Development 26:891-907.

Tsai H-H, Li H*, Fuentealba LC*, Molofsky AV*, Taveira-Marques R, Zhuang H, Tenney A, Murnen AT, Fancy SPJ, Merkle F, et al. 2012. Regional astrocyte allocation regulates CNS synaptogenesis and repair. Science 337: 358–362.

Tien A-C, Tsai H-H, Molofsky AV, McMahon M, Foo LC, Kaul A, Dougherty JD, Heintz N, Gutmann DH, Barres BA, et al. 2012. Regulated temporal-spatial astrocyte precursor cell proliferation involves BRAF signalling in mammalian spinal cord. Development 139: 2477–2487.

He S, Iwashita T, Buchstaller J, Molofsky AV, Thomas D, Morrison SJ (2009.) Bmi-1 over-expression in neural stem/progenitor cells increases proliferation and neurogenesis in culture but has little effect on these functions in vivo. Developmental Biology 328(2):257-72.

Molofsky, A. V.*, Slutsky, S. G.*, Joseph, N.M., He, S-H. Pardal, R., Krishnamurthy J., Sharpless, N.E., and Morrison, S. J. (2006). Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature 443: 448-52.

Molofsky, A.V., He, S., Bydon, M., Morrison, S.J., and Pardal, R. (2005). Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways. Genes and Development 19:1432-1437.

Pardal, R., Molofsky, A. V., He, S., and Morrison, S. J. (2005). Stem cell self-renewal and cancer cell proliferation are regulated by common networks that balance the activation of proto-oncogenes and tumor suppressors. Cold Spring Harbor Symposia on Quantitative Biology 70: 177-185.

Molofsky, A. V., Pardal, R., and Morrison, S. J. (2004). Diverse mechanisms regulate stem cell self-renewal. Current Opinion in Cell Biology 16(6): 700-707.

Molofsky, A.V.*, Pardal,R.*, Iwashita,T., Park,I.K., Clarke,M.F., and Morrison,S.J. (2003.) Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature 425:962-967.